It has been shown that kynurenic acid possesses neuroactive activity.
2.
Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.
3.
In 1904 he isolated kynurenic acid from the urine of dogs that had been fed tryptophan.
4.
As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders.
5.
Inhibition of kynurenine 3-monooxygenase leads to an increase of kynurenic acid in the kynurenine pathway.
6.
Kynureninase catabolizes the conversion of kynurenine into anthranilic acid while kynurenine-oxoglutarate transaminase catabolizes its conversion into kynurenic acid.
7.
Another function of GOT2 is that it is believed to transaminate kynurenine into kynurenic acid ( KYNA ) in the brain.
8.
Kynurenic acid was discovered in 1853 by the German chemist Justus von Liebig in dog urine, which it was apparently named after.
9.
High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency / absence of kynureninase.
10.
One of these kynurenines, aptly named kynurenic acid, serves as a neuroprotectant through its function as an nicotinic and glutamate receptors ( responsive to the neurotransmitters nicotine and glutamate, respectively ).
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